| Secretary of State | Lewis Cass, 1857
Jeremiah S. Black, 1860 |
| Secretary of the Treasury | Howell Cobb, 1857
Philip F. Thomas, 1860
John A. Dix, 1861 |
| Secretary of War | John B. Floyd, 1857
Joseph Holt, 1861 |
| Attorney General | Jeremiah S. Black, 1857
Edwin M. Stanton, 1860 |
| Postmaster General | Aaron V. Brown, 1857
Joseph Holt, 1859
Horatio King, 1861 |
| Secretary of the Navy | Isaac Toucey, 1857 |
| Secretary of the Interior | Jacob Thompson, 1857 |
