| Secretary of State | William H. Seward, 1861 |
| Secretary of the Treasury | Salmon P. Chase, 1861
William P. Fessenden, 1864
Hugh McCulloch, 1865 |
| Secretary of War | Simon Cameron, 1861
Edwin M. Stanton, 1862 |
| Attorney General | Edward Bates, 1861
James Speed, 1864 |
| Postmaster General | Montgomery Blair, 1861
William Dennison, 1864 |
| Secretary of the Navy | Gideon Welles, 1861 |
| Secretary of the Interior | Caleb B. Smith, 1861
John P. Usher, 1863 |
